Your question doesn't make sense because your expression only has numbers in it. It has no letters so it cannot be a function. There is nowhere to sub x=anything in because there is no x!
This is the value of the numerical expression. 
$${\frac{\left({\mathtt{\,-\,}}{{\mathtt{1.001}}}^{{\mathtt{6}}}{\mathtt{\,-\,}}{\mathtt{1}}\right)}{\left({\mathtt{\,-\,}}{{\mathtt{1.001}}}^{{\mathtt{3}}}{\mathtt{\,\small\textbf+\,}}{\mathtt{1}}\right)}} = {\mathtt{668.003\: \!447\: \!223\: \!296\: \!296\: \!3}}$$
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